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Used as cell-permeable, irreversible inhibitor of caspase activity. R&D Systems Pan Caspase Inhibitor Z-VAD-FMK binds to the active site of activated proteases irreversibly and inhibits apoptosis.
Competitive serine protease inhibitor
Non-selective P2 agonist; analog of ATP (Cat. No. 3245)
Potent calcineurin inhibitor; immunosuppressant
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
Potent and selective PERK inhibitor; orally bioavailable
Reagent used in the measurement of cell proliferation
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
Potent and selective allosteric inhibitor of Wip1 phosphatase
Potent and selective Lck and Src inhibitor; also inhibits SIK
Potent and selective G9a/GLP inhibitor
Potent LIM kinase inhibitor; antitumor
Positive allosteric modulator of α4β2 nAChRs
Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
Potent and selective ALDH2 inhibitor