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Tocris Bioscience™ GSK 2830371
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Product Code. 18762978
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 18762978

Brand: Tocris Bioscience™ 5140/10

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This item is not returnable. View return policy

Description

Potent and selective allosteric inhibitor of Wip1 phosphatase

GSK 2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo. Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 10 mg
Product Type GSK 2830371
Purity >98%
Molecular Weight (g/mol) 461.02
Inhibitors GSK 2830371

For Research Use Only

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