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CAS RN 1110813-31-4

CAS RN 1110813-31-4

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1

Tocris Bioscience™ Dacomitinib
GREENER_CHOICE

Potent irreversible pan ErbB inhibitor

CAS 1110813-31-4
Chemical Name or Material (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Recommended Storage Store at 4°C
Molecular Formula C24H25ClFN5O2
Formula Weight Observed MW: 469.94
Assay Percent Range >98%
2

Dacomitinib, TRC

CAS: 1110813-31-4 Chemical Name or Material: Dacomitinib Formula Weight: 469.1681 InChI Formula: InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+ IUPAC Name: (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Molecular Formula: C24 H25 Cl F N5 O2 Molecular Weight (g/mol): 469.94 Recommended Storage: 4°C SMILES: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN4CCCCC4 Synonym: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-, (2E)-,(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide,Dacomitinib,PF 00299804,PF 299,PF 299804

CAS 1110813-31-4
Molecular Weight (g/mol) 469.94
InChI Formula InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
Chemical Name or Material Dacomitinib
Synonym 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-, (2E)-,(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide,Dacomitinib,PF 00299804,PF 299,PF 299804
SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN4CCCCC4
Recommended Storage 4°C
Molecular Formula C24 H25 Cl F N5 O2
IUPAC Name (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
Formula Weight 469.1681
3

Dacomitinib, MedChemExpress

MedChemExpress Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 469.94
Color Light Yellow
Physical Form Solid
Chemical Name or Material Dacomitinib
Grade Research
SMILES O=C(/C=C/CN1CCCCC1)NC2=CC3=C(C=C2OC)N=CN=C3NC4=CC=C(C(Cl)=C4)F
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.0%
CAS 1110813-31-4
Solubility Information DMSO : 40 mg/mL (85.12 mM; Need ultrasonic)
Synonym PF-00299804 PF-299804
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H25ClFN5O2
Formula Weight 469.94