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SKI II, Tocris Bioscience™
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Product Code. 18045192
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18045192 50 mg 50mg
18024882 10 mg 10mg
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Product Code. 18045192 Supplier Tocris Bioscience Supplier No. 2097/50

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Description

Selective non-lipid inhibitor of sphingosine kinase

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 312636-16-1
Molecular Formula C15H11ClN2OS
Molecular Weight (g/mol) 302.776
InChI Key ZFGXZJKLOFCECI-UHFFFAOYSA-N
Synonym ski ii, 4-4-4-chlorophenyl-2-thiazolyl amino phenol, skiii, sphk-i2, 4-4-4-chlorophenyl-1,3-thiazol-2-yl amino phenol, sphingosine kinase inhibitor 2, 4-4-4-chlorophenyl thiazol-2-ylamino phenol, phenol, 4-4-4-chlorophenyl-2-thiazolyl amino, 3vzd
PubChem CID 753704
IUPAC Name 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
SMILES C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

Specifications

Quantity 50 mg
Formula Weight 302.78
Percent Purity >98%
Chemical Name or Material SKI II
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