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  8. RN-1734, MedChemExpress

RN-1734, MedChemExpress

Product Code. 16450458
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Product Code. 16450458

Brand: Medchem Express HY19975

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Description

MedChemExpress RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

Specifications

Chemical Name or Material RN-1734
CAS 946387-07-1
Color White
Purity Grade Notes Research
Molecular Formula C14H22Cl2N2O2S
Quantity 5 mg
Solubility Information DMSO : 25 mg/mL (70.76 mM; ultrasonic and warming and heat to 60°C)
SMILES O=S(C1=CC=C(Cl)C=C1Cl)(N(C(C)C)CCNC(C)C)=O
Molecular Weight (g/mol) 353.31
Formula Weight 353.31
Percent Purity 98.99%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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