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  8. PF-915275, MedChemExpress

PF-915275, MedChemExpress

Product Code. 16429937
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Product Code. 16429937

Brand: Medchem Express HY18056

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Description

MedChemExpress PF-915275 is a potent, selective and orally active human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.

PF-915275 is a potent, selective and orally active human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.

Specifications

Chemical Name or Material PF-915275
CAS 857290-04-1
Color Off-White
Purity Grade Notes Research
Molecular Formula C18H14N4O2S
Quantity 5 mg
Solubility Information DMSO : ≥ 31 mg/mL (88.47 mM)
SMILES N#CC1=CC=C(C2=CC=C(S(NC3=NC(N)=CC=C3)(=O)=O)C=C2)C=C1
Molecular Weight (g/mol) 350.39
Formula Weight 350.39
Percent Purity 98.01%
Grade Research
Physical Form Solid
For Use With (Application) Metabolism-sugar/lipid metabolism
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Research purposes only

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