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KN-62, MedChemExpress

Product Code. 16478317
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16478317 5 mg 5mg
16425628 10 mg 10mg
16411797 50 mg 50mg
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Product Code. 16478317 Supplier Medchem Express Supplier No. HY13290

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Description

MedChemExpress KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.

KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.

Spécification

Chemical Name or Material KN-62
CAS 127191-97-3
Color Yellow
Purity Grade Notes Research
Molecular Formula C38H35N5O6S2
Quantity 5 mg
Solubility Information DMSO : ≥ 100 mg/mL (138.53 mM)
SMILES O=C(N1CCN(C2=CC=CC=C2)CC1)[C@H](CC3=CC=C(C=C3)OS(=O)(C4=CC=CC5=C4C=CN=C5)=O)N(C)S(=O)(C6=CC=CC7=C6C=CN=C7)=O
Molecular Weight (g/mol) 721.84
Formula Weight 721.84
Percent Purity 98.27%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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