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ARS-853, MedChemExpress

Product Code. 16493797
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Product Code. 16493797

Brand: Medchem Express HY19706

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Description

MedChemExpress ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

Specifications

Chemical Name or Material ARS-853
CAS 1629268-00-3
Color White
Purity Grade Notes Research
Molecular Formula C22H29ClN4O3
Quantity 50 mg
Solubility Information DMSO : 33.33 mg/mL (76.99 mM; Need ultrasonic)
SMILES ClC1=C(C2(C)CC2)C=C(NCC(N3CCN(C4CN(C(C=C)=O)C4)CC3)=O)C(O)=C1
Molecular Weight (g/mol) 432.94
Formula Weight 432.94
Percent Purity 98.04%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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