CAS RN 471905-41-6

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MK-0752, MedChemExpress

MedChemExpress MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.

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Specifications

Molecular Weight (g/mol)	442.9
Color	White
Physical Form	Solid
Chemical Name or Material	MK-0752
Grade	Research
SMILES	O=S([C@@]1(C2=C(C=CC(F)=C2)F)CC[C@@H](CCC(O)=O)CC1)(C3=CC=C(Cl)C=C3)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	95.0%
CAS	471905-41-6
Solubility Information	DMSO : ≥ 100 mg/mL (225.78 mM) ∣Ethanol : 10 mg/mL (22.58 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₁ClF₂O₄S
Formula Weight	442.9

CAS RN 471905-41-6

CAS RN 471905-41-6

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