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MK-0752, MedChemExpress

Product Code. 16480647
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Product Code. 16480647 Supplier Medchem Express Supplier No. HY10974

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Description

MedChemExpress MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.

MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.

Specifications

Chemical Name or Material MK-0752
CAS 471905-41-6
Color White
Purity Grade Notes Research
Molecular Formula C21H21ClF2O4S
Quantity 50 mg
Solubility Information DMSO : ≥ 100 mg/mL (225.78 mM) ∣Ethanol : 10 mg/mL (22.58 mM; Need ultrasonic)
SMILES O=S([C@@]1(C2=C(C=CC(F)=C2)F)CC[C@@H](CCC(O)=O)CC1)(C3=CC=C(Cl)C=C3)=O
Molecular Weight (g/mol) 442.9
Formula Weight 442.9
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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