CAS RN 280744-09-4

IUPAC Name: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

Synonyms: 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione

Molecular Weight (g/mol): 371.22

Molecular Formula: C19H12Cl2N2O2

InChi Key: JCSGFHVFHSKIJH-UHFFFAOYSA-N

SMILES: CN1C=C(C2=CC=CC=C12)C1=C(C(=O)NC1=O)C1=CC=C(Cl)C=C1Cl

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CAS: 280744-09-4 Molecular Formula: C19H12Cl2N2O2

CAS	280744-09-4
Molecular Formula	C19H12Cl2N2O2

WNT pathway activator; Inhibits GSK3α and GSK3β

MedChemExpress SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC50s of 34.3 nM for both GSK-3α and GSK-3β.

Molecular Weight (g/mol)	371.22
Color	Orange Red
Physical Form	Powder
Chemical Name or Material	SB 216763
Grade	Research
SMILES	O=C(NC1=O)C(C2=CC=C(C=C2Cl)Cl)=C1C3=CN(C4=C3C=CC=C4)C
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.92%
CAS	280744-09-4
Solubility Information	DMSO : 100 mg/mL (269.38 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₂Cl₂N₂O₂
Formula Weight	371.22