CAS RN 1033769-28-6
CAS RN 1033769-28-6
IUPAC Name:
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-({2-oxo-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-6-yl}amino)phenyl]urea
Synonyms:
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-(4-methyl-3-{[2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino}phenyl)urea
Molecular Weight (g/mol):
535.5
Molecular Formula:
C28H21F4N5O2
InChi Key:
YYDUWLSETXNJJT-UHFFFAOYSA-N
SMILES:
CC1=C(NC2=CC3=C(C=C2)C(=CC2=CC=CN2)C(=O)N3)C=C(NC(=O)NC2=C(F)C=CC(=C2)C(F)(F)F)C=C1
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Tocris Bioscience™ GNF 5837
CAS: 1033769-28-6 Molecular Formula: C28H21F4N5O2
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GNF-5837, MedChemExpress
MedChemExpress GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) .
