Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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1 – 15 of 113 results

Emapunil, MedChemExpress

MedChemExpress Emapunil (AC-5216), an orally active and selective TSPO (a mitochondrial benzodiazepine receptor) ligand, produces anti-anxiety and antidepressant-like effects in various animal models.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	401.46
Color	White
Physical Form	Solid
Chemical Name or Material	Emapunil
Grade	Research
SMILES	O=C(N(CC)CC1=CC=CC=C1)CN2C(N(C)C3=CN=C(C4=CC=CC=C4)N=C23)=O
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	99.26%
CAS	226954-04-7
Solubility Information	DMSO : 33.33 mg/mL (83.02 mM; Need ultrasonic)
Health Hazard 1	H302
Synonym	AC-5216 XBD-173
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₂₃N₅O₂
Formula Weight	401.46

AF64394, MedChemExpress

MedChemExpress AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	393.87
Color	White
Physical Form	Solid
Chemical Name or Material	AF64394
Grade	Research
SMILES	ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Percent Purity	98.02%
CAS	1637300-25-4
Solubility Information	DMSO : ≥ 125 mg/mL (317.36 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₀ClN₅O
Formula Weight	393.87

PRT-060318, MedChemExpress

MedChemExpress PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	340.42
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	PRT-060318
Grade	Research
SMILES	O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.04%
CAS	1194961-19-7
Solubility Information	H2O : 5.6 mg/mL (16.45 mM; Need ultrasonic and warming)
Synonym	PRT318
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₂₄N₆O
Formula Weight	340.42

ML347, MedChemExpress

MedChemExpress ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	352.39
Color	Yellow
Physical Form	Solid
Chemical Name or Material	ML347
Grade	Research
SMILES	COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.85%
CAS	1062368-49-3
Solubility Information	DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)
Synonym	LDN 193719
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₁₆N₄O
Formula Weight	352.39

GSK2334470, MedChemExpress

MedChemExpress GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	462.59
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	GSK2334470
Grade	Research
SMILES	O=C([C@@H]1CN(C2=NC(NC)=NC(C3=CC4=C(C=C3)C(N)=NN4)=C2)[C@H](C)CC1)NC5CCCCC5
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.73%
CAS	1227911-45-6
Solubility Information	DMSO : ≥ 50 mg/mL (108.09 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₄N₈O
Formula Weight	462.59

EED226, MedChemExpress

MedChemExpress EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model. EED226 is a potent, selective, and orally bioavailable EED inhibitor. EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	369.4
Color	Off-White
Physical Form	Solid
Chemical Name or Material	EED226
Grade	Research
SMILES	O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.61%
CAS	2083627-02-3
Solubility Information	DMSO : ≥ 29 mg/mL (78.51 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₇H₁₅N₅O₃S
Formula Weight	369.4

VUF10460, MedChemExpress

MedChemExpress VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	269.34
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	VUF10460
Grade	Research
SMILES	NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.0%
CAS	1028327-66-3
Solubility Information	DMSO : 50 mg/mL (185.64 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₅H₁₉N₅
Formula Weight	269.34

HJB97, MedChemExpress

MedChemExpress HJB97 is a high-affinity BET inhibitor with Kis of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. HJB97 is employed for the design of potential PROTAC BET degrader and has antitumor activity.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	500.55
Color	Yellow
Physical Form	Solid
Chemical Name or Material	HJB97
Grade	Research
SMILES	O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NC
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.24%
CAS	2093391-24-1
Solubility Information	DMSO : 30 mg/mL (59.93 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₂₈N₈O₃
Formula Weight	500.55

WAY-600, MedChemExpress

MedChemExpress WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	494.59
Color	White
Physical Form	Solid
Chemical Name or Material	WAY-600
Grade	Research
SMILES	C1(C=CN2)=C2C=CC(C3=NC(N(C4CCN(CC5=CC=CN=C5)CC4)N=C6)=C6C(N7CCOCC7)=N3)=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.12%
CAS	1062159-35-6
Solubility Information	DMSO : 50 mg/mL (101.09 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₃₀N₈O
Formula Weight	494.59

AZ20, MedChemExpress

MedChemExpress AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	412.51
Color	Off-White
Physical Form	Solid
Chemical Name or Material	AZ20
Grade	Research
SMILES	O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.92%
CAS	1233339-22-4
Solubility Information	DMSO : ≥ 100 mg/mL (242.42 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₄N₄O₃S
Formula Weight	412.51

PF-06928215, MedChemExpress

MedChemExpress PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μμ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).

Pricing and Availability

G-749, MedChemExpress

MedChemExpress G-749 is a potent, oral active and ATP competitive FLT3 inhibitor, with IC50s of 0.4 nM and 0.6 nM for FLT3 wild type and FLT3-D835Y, respectively. G-749 can be used for the research of drug resistance for acute myeloid leukemia (AML).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	521.41
Color	Off-White
Physical Form	Solid
Chemical Name or Material	G-749
Grade	Research
SMILES	O=C1C2=C(N=C(NC3CCN(C)CC3)N=C2NC4=CC=C(OC5=CC=CC=C5)C=C4)C(Br)=CN1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.0%
CAS	1457983-28-6
Solubility Information	DMSO : 25 mg/mL (47.95 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₅BrN₆O₂
Formula Weight	521.41

Filorexant, MedChemExpress

MedChemExpress Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	420.48
Color	Light Brown
Physical Form	Powder
Chemical Name or Material	Filorexant
Grade	Research
SMILES	CC1=CC(C(N2C[C@H](COC3=CC=C(F)C=N3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.95%
CAS	1088991-73-4
Solubility Information	DMSO : 100 mg/mL (237.82 mM; Need ultrasonic)
Synonym	MK-6096
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₅FN₄O₂
Formula Weight	420.48

LDN-212854, MedChemExpress

MedChemExpress LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM). LDN-212854 also inhibits ALK1 (IC50: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	406.48
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	LDN-212854
Grade	Research
SMILES	C12=C(C3=C4N=CC(C5=CC=C(N6CCNCC6)C=C5)=CN4N=C3)C=CC=C1N=CC=C2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.65%
CAS	1432597-26-6
Solubility Information	DMSO : ≥ 30 mg/mL (73.80 mM)
Health Hazard 1	H301
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₂N₆
Formula Weight	406.48

BML-284, MedChemExpress

MedChemExpress BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	350.37
Color	White
Physical Form	Powder
Chemical Name or Material	BML-284
Grade	Research
SMILES	NC1=NC(C2=CC=CC(OC)=C2)=CC(NCC3=CC=C(OCO4)C4=C3)=N1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	97.48%
CAS	853220-52-7
Solubility Information	DMSO : ≥ 100 mg/mL (285.41 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₈N₄O₃
Formula Weight	350.37

Pyrimidines And Derivatives

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