Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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1 – 15 of 113 results

EED226, MedChemExpress

MedChemExpress EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model. EED226 is a potent, selective, and orally bioavailable EED inhibitor. EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	369.4
Color	Off-White
Physical Form	Solid
Chemical Name or Material	EED226
Grade	Research
SMILES	O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.61%
CAS	2083627-02-3
Solubility Information	DMSO : ≥ 29 mg/mL (78.51 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₇H₁₅N₅O₃S
Formula Weight	369.4

HJB97, MedChemExpress

MedChemExpress HJB97 is a high-affinity BET inhibitor with Kis of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. HJB97 is employed for the design of potential PROTAC BET degrader and has antitumor activity.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	500.55
Color	Yellow
Physical Form	Solid
Chemical Name or Material	HJB97
Grade	Research
SMILES	O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NC
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.24%
CAS	2093391-24-1
Solubility Information	DMSO : 30 mg/mL (59.93 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₂₈N₈O₃
Formula Weight	500.55

PRT-060318, MedChemExpress

MedChemExpress PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	340.42
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	PRT-060318
Grade	Research
SMILES	O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.04%
CAS	1194961-19-7
Solubility Information	H2O : 5.6 mg/mL (16.45 mM; Need ultrasonic and warming)
Synonym	PRT318
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₂₄N₆O
Formula Weight	340.42

AZ20, MedChemExpress

MedChemExpress AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	412.51
Color	Off-White
Physical Form	Solid
Chemical Name or Material	AZ20
Grade	Research
SMILES	O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.92%
CAS	1233339-22-4
Solubility Information	DMSO : ≥ 100 mg/mL (242.42 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₄N₄O₃S
Formula Weight	412.51

ML347, MedChemExpress

MedChemExpress ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	352.39
Color	Yellow
Physical Form	Solid
Chemical Name or Material	ML347
Grade	Research
SMILES	COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.85%
CAS	1062368-49-3
Solubility Information	DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)
Synonym	LDN 193719
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₁₆N₄O
Formula Weight	352.39

WAY-600, MedChemExpress

MedChemExpress WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	494.59
Color	White
Physical Form	Solid
Chemical Name or Material	WAY-600
Grade	Research
SMILES	C1(C=CN2)=C2C=CC(C3=NC(N(C4CCN(CC5=CC=CN=C5)CC4)N=C6)=C6C(N7CCOCC7)=N3)=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.12%
CAS	1062159-35-6
Solubility Information	DMSO : 50 mg/mL (101.09 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₃₀N₈O
Formula Weight	494.59

VUF10460, MedChemExpress

MedChemExpress VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	269.34
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	VUF10460
Grade	Research
SMILES	NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.0%
CAS	1028327-66-3
Solubility Information	DMSO : 50 mg/mL (185.64 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₅H₁₉N₅
Formula Weight	269.34

G-749, MedChemExpress

MedChemExpress G-749 is a potent, oral active and ATP competitive FLT3 inhibitor, with IC50s of 0.4 nM and 0.6 nM for FLT3 wild type and FLT3-D835Y, respectively. G-749 can be used for the research of drug resistance for acute myeloid leukemia (AML).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	521.41
Color	Off-White
Physical Form	Solid
Chemical Name or Material	G-749
Grade	Research
SMILES	O=C1C2=C(N=C(NC3CCN(C)CC3)N=C2NC4=CC=C(OC5=CC=CC=C5)C=C4)C(Br)=CN1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.0%
CAS	1457983-28-6
Solubility Information	DMSO : 25 mg/mL (47.95 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₅BrN₆O₂
Formula Weight	521.41

GSK2334470, MedChemExpress

MedChemExpress GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	462.59
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	GSK2334470
Grade	Research
SMILES	O=C([C@@H]1CN(C2=NC(NC)=NC(C3=CC4=C(C=C3)C(N)=NN4)=C2)[C@H](C)CC1)NC5CCCCC5
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.73%
CAS	1227911-45-6
Solubility Information	DMSO : ≥ 50 mg/mL (108.09 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₄N₈O
Formula Weight	462.59

AF64394, MedChemExpress

MedChemExpress AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	393.87
Color	White
Physical Form	Solid
Chemical Name or Material	AF64394
Grade	Research
SMILES	ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Percent Purity	98.02%
CAS	1637300-25-4
Solubility Information	DMSO : ≥ 125 mg/mL (317.36 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₀ClN₅O
Formula Weight	393.87

Lck Inhibitor, MedChemExpress

MedChemExpress Lck Inhibitor is a potent, orally active Lck (lymphocyte specific kinase) inhibitor with IC50s of 7, 2.1, 4.2 and 200 nM for Lck, Lyn, Src and Syk kinases, respectively. Lck Inhibitor shows >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Lck Inhibitor inhibits T cell proliferation and in vivo models of arthritis.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	530.62
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Lck Inhibitor
Grade	Research
SMILES	O=C1N(C2=C(C)C=CC=C2C)C3=NC4=CC=CC=C4N3C5=NC(NC6=CC=C(N7CCN(C)CC7)C=C6)=NC=C15
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.2%
CAS	847950-09-8
Solubility Information	DMSO : 100 mg/mL (188.46 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₁H₃₀N₈O
Formula Weight	530.62

mTOR inhibitor-3, MedChemExpress

MedChemExpress mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	474.56
Color	White
Physical Form	Solid
Chemical Name or Material	mTOR inhibitor-3
Grade	Research
SMILES	O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C4C(CN(C5=NC=CC=N5)CC4)=N2)C=C1)NCC
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.58%
CAS	1207358-59-5
Solubility Information	DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₀N₈O₂
Formula Weight	474.56

ALLO-2, MedChemExpress

MedChemExpress ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	371.32
Color	Yellow
Physical Form	Solid
Chemical Name or Material	ALLO-2
Grade	Research
SMILES	FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.58%
CAS	1357350-60-7
Solubility Information	DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₂F₃N₅O
Formula Weight	371.32

GDC-0349, MedChemExpress

MedChemExpress GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	452.55
Color	Yellow
Physical Form	Solid
Chemical Name or Material	GDC-0349
Grade	Research
SMILES	O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	1207360-89-1
Solubility Information	DMSO : ≥ 100 mg/mL (220.97 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₃₂N₆O₃
Formula Weight	452.55

EPZ015666, MedChemExpress

MedChemExpress EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC50 of 22 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	383.44
Color	White
Physical Form	Solid
Chemical Name or Material	EPZ015666
Grade	Research
SMILES	O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4COC4)=NC=N3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.96%
CAS	1616391-65-1
Solubility Information	DMSO : 100 mg/mL (260.80 mM; Need ultrasonic)
Synonym	GSK3235025
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₂₅N₅O₃
Formula Weight	383.44

Pyrimidines And Derivatives

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