CAS RN 284035-33-2

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NPS-2143, MedChemExpress

MedChemExpress NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor.

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Specifications

Molecular Weight (g/mol)	408.92
Color	Off-White
Physical Form	Solid
Chemical Name or Material	NPS-2143
Grade	Research
SMILES	N#CC1=C(OC[C@@H](CNC(C)(CC2=CC=C3C=CC=CC3=C2)C)O)C=CC=C1Cl
For Use With (Application)	Metabolism-protein/nucleotide metabolism
Percent Purity	98.09%
CAS	284035-33-2
Solubility Information	DMSO : 17.86 mg/mL (43.68 mM; ultrasonic and adjust pH to 2 with H2O)
Synonym	SB-262470A
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₅ClN₂O₂
Formula Weight	408.92

CAS RN 284035-33-2

CAS RN 284035-33-2

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