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Invitrogen™ ZIP14 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA521077
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Description
Suggested positive controls are human liver, mouse kidney, or rat kidney tissue lysates. PA5-21077 can be used with blocking peptide PEP-1191. Predicted species reactivity based on immunogen sequence: Bovine: (94%). At least three isoforms of ZIP14 are known to exist; this antibody will detect all isoforms. ZIP14 antibody is predicted to not cross-react with other ZIP family members.
The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.
Specifications
| ZIP14 | |
| Polyclonal | |
| Unconjugated | |
| SLC39A14 | |
| cig19; Factor for adipocyte differentiation 123; Fad123; FAD-123; HMNDYT2; Kiaa0062; LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; NET34; SLC39A14; solute carrier family 39 (metal ion transporter), member 14; solute carrier family 39 (zinc transporter), member 14; solute carrier family 39 member 14; Zinc transporter ZIP14; Zip14; ZIP-14; Zrt- and Cig19; Zrt- and Irt-like protein 14; Zrt-, Irt-like protein 14 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 213053, 23516, 306009 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q15043, Q75N73 | |
| SLC39A14 | |
| A peptide corresponding to 16 amino acid synthetic peptide near the center of human ZIP14. The immunogen is located within amino acids 230-280 of ZIP14. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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