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Invitrogen™ Zenon™ pHrodo™ iFL IgG Labeling Reagents

Zenon™ pHrodo™ iFL Green-labeled or Red-labeled Fab fragments (i.e. labeling reagent) are directed against the Fc portion of an intact IgG primary antibody to form a labeling complex.

993.00 € - 3705.00 €

Specifications

Product Type Labeling Reagent
Labeling Target IgG
Label Type pHrodo™ (pH sensitive)
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Products 8
Product Code Brand Species Labeling Target Description Color Price Quantity & Availability  
Product Code Brand Species Labeling Target Description Color Price Quantity & Availability  
16334925
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Invitrogen™
Z25609
Mouse IgG pHrodo™ iFL Green, 240 μL Green
1084.00 €
240µL
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Estimated Shipment: 11-04-2024
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17964691
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Invitrogen™
Z25618
Human IgG pHrodo™ Deep Red, 240 μL Deep Red
993.00 €
240µL
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Estimated Shipment: 19-04-2024
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16344925
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Invitrogen™
Z25610
Mouse IgG pHrodo™ iFL Red, 240 μL Red
1092.00 €
240µL
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17924701
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Invitrogen™
Z25622
Mouse IgG pHrodo™ Deep Red, 240 μL Deep Red
993.00 €
240µL
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Estimated Shipment: 19-04-2024
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15871527
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Invitrogen™
Z25611
Human IgG pHrodo™ iFL Green, 240 μL Green
1068.00 €
Each
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Estimated Shipment: 12-04-2024
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16099321
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Invitrogen™
Z25612
Human IgG pHrodo™ iFL Red, 240 μL Red
1068.00 €
240µL
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In Stock
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17835097
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Invitrogen™
Z25613
Human IgG pHrodo™ iFL Green, 1.2 mL Green
3705.00 €
1.20mL
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Estimated Shipment: 19-04-2024
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17865247
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Invitrogen™
Z25614
Human IgG pHrodo™ iFL Red, 1.2 mL Red
3705.00 €
1.20mL
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Estimated Shipment: 19-04-2024
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Description

Description

Streamline antibody-drug conjugate screening campaigns with Invitrogen Zenon pHrodo IgG Labeling Reagents to screen for antibody internalization. These reagents provide rapid, scalable antibody labeling and give a bright fluorescence-based indication of antibody uptake and trafficking in target cells when analyzed by flow cytometry, fluorescence microscopy, or high-content screening.

Zenon™ pHrodo™ iFL Green-labeled or Red-labeled Fab fragments (i.e. labeling reagent) are directed against the Fc portion of an intact IgG primary antibody to form a labeling complex. Formation of the Fab–antibody complex occurs in fewer than 5 minutes. Because the pHrodo™ iFL dyes dramatically increase in fluorescence as the pH of their surroundings becomes more acidic, the antibodies coupled with the Zenon™ pHrodo™ iFL IgG Labeling Reagents provide an excellent measure of endocytic activity based on the acidification of the labeled antibodies as they are ingested by the cell.

The Zenon™ pHrodo™ iFL IgG Labeling Reagents contain sufficient material to label one to four 96-well plates, depending on the Zenon™ labeling reagent concentration used. Only a small amount of starting material is needed, and the method is optimized for efficient labeling of antibodies in serum, ascites fluid, or hybridoma suspensions.

Other advantages of the pH-sensitive Zenon™ pHrodo™ iFL IgG Labeling Reagents include:

Simplicity—No reagent purification is required
Accuracy—No wash steps or quenchers are needed, minimizing cross-reactivity or background
Speed—Labeled antibodies are typically ready to use in 10 minutes
Specificity—Dyes are designed for the specific detection of phagocytosis and endocytosis

Preserve primary antibody function and affinities
Reactive dye labeling of primary antibodies can have unpredictable and undesirable outcomes. One of these is reduced binding affinity due to label addition in the binding pocket. The Zenon™ antibody labeling approach, which is targeted to the Fc tail, resolves this potential issue.

Try custom antibody conjugates
If the antibody conjugate you need is not available as one of our stocked products, we will prepare a custom antibody conjugate for you. Our custom conjugation service is efficient and confidential, and we stand by the quality of our work. We are ISO 13485:2000 certified.

For Research Use Only. Not intended for animal or human therapeutic or diagnostic use.

Specifications

Specifications

Labeling Reagent
IgG
pHrodo™ (pH sensitive)
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