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Invitrogen™ ZBTB5 Polyclonal Antibody

Product Code. 16347354
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16347354 100 μL 100µL
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Product Code. 16347354 Supplier Invitrogen™ Supplier No. PA578660

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Description

Rabbit Polyclonal Antibody

Predicted Reactivity: Human (100%), Xenopus laevis (81%), Rhesus Monkey (99%), Bovine (96%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBTB5
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.87 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene ZBTB5
Gene Accession No. O15062, Q7TQG0
Gene Alias 5930421I10; 9430083K24Rik; AI646847; expressed in brain and neural tube; Kiaa0354; mKIAA0354; RP11-397D12.5; Transcription factor ZNF-POZ; ZBTB5; zinc finger and BTB domain containing 5; zinc finger and BTB domain-containing protein 5
Gene Symbols ZBTB5
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human ZBTB5. The exact sequence is proprietary.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230119, 298084, 9925
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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