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Invitrogen™ ZBTB5 Polyclonal Antibody

Product Code. 12809232
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Quantity:
100 μg
Unit Size:
100µg
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12809232 100 μg 100µg
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Product Code. 12809232 Supplier Invitrogen™ Supplier No. PA521085

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-21085 can be used with blocking peptide PEP-1199.

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZBTB5
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ZBTB5
Gene Accession No. O15062, Q7TQG0
Gene Alias 5930421I10; 9430083K24Rik; AI646847; expressed in brain and neural tube; Kiaa0354; mKIAA0354; RP11-397D12.5; Transcription factor ZNF-POZ; ZBTB5; zinc finger and BTB domain containing 5; zinc finger and BTB domain-containing protein 5
Gene Symbols ZBTB5
Host Species Rabbit
Immunogen A 16 amino acid peptide near the carboxy terminus of human ZBTB6.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230119, 298084, 9925
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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