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Tocris Bioscience™ (Z)-4-Hydroxytamoxifen
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Product Code. 30001481
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 30001481

Brand: Tocris Bioscience™ 3412/10

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This item is not returnable. View return policy

Description

Metabolite of tamoxifen (Cat. No. 0999)

(Z)-4-Hydroxytamoxifen is an estrogen receptor antagonist (IC50 = 27 μM). (Z)-4-Hydroxytamoxifen is a Tamoxifen (Cat. No. 0999) metabolite; that exhibits greater potency than the parent compound. (Z)-4-Hydroxytamoxifen Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ∽25-fold higher specificity than wtCas9. (Z)-4-Hydroxytamoxifen binds to voltage-gated sodium channels, near the intracellular gate and inhibits the sodium current by delaying channel recovery from the inactivated state (IC50 values are 297 nM and 2.1 μM for NavM and human Nav, respectively in HEK cells); this inhibition is independent of estrogen receptor modulation. Chemotherapeutic agent.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 68047-06-3
Molecular Formula C26H29NO2

Specifications

Quantity 10 mg
Formula Weight 387.51
Purity >98%
Molecular Weight (g/mol) 387.523
Chemical Name or Material (Z)-4-Hydroxytamoxifen
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