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Tocris Bioscience™ VX 765

Product Code. 18787576
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18787576 10 mg 10mg
18717036 50 mg 50mg
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Product Code. 18787576 Supplier Tocris Bioscience™ Supplier No. 7143/10

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121.60 EUR valid until 2026-03-31
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Description

High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable

VX 765 is a high affinity and selective caspase-4 and caspase 1/ICE inhibitor (Ki of <0.6 and 0.8 nM, respectively). Prodrug of VRT-043198. Inhibits LPS-induced IL-1β production ∼ 60% in collagen-induced arthritis mouse model. Exhibits anticonvulsant effects in mouse model of acute seizures. Anti-inflammatory. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2 R,3 S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide
CAS 273404-37-8
Quantity 10 mg
Target Caspase Inhibitors
Molecular Formula C24H33ClN4O6
Purity 0.98
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