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Invitrogen™ Vinculin Polyclonal Antibody

Product Code. 13483917
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
13483917 100 μL 100µL
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Product Code. 13483917 Supplier Invitrogen™ Supplier No. PA529688

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, Mouse brain, HeLa. Predicted reactivity: Human (99%), Mouse (98%), Rat (98%), Pig (98%), Chicken (93%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Vinculin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene VCL
Gene Accession No. P18206, P85972, Q64727
Gene Alias 9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; metavinculin; meta-vinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; unnamed protein product; Vcl; vcl {ECO:0000250; VIN; vinc; vinc 1; VINC1; Vinculin; vinculin {ECO:0000250
Gene Symbols VCL
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Vinculin. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22330, 305679, 7414
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

compliance-icons
Product Identifier
  • Vinculin Polyclonal Antibody
 Signal Word
  • Warning
 Hazard Category
  • Skin sensitiser Category 1
 Hazard Statement
  • H317-May cause an allergic skin reaction.
 Precautionary Statement
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P272-Contaminated work clothing should not be allowed out of the workplace.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
  • P362+P364-Take off contaminated clothing and wash it before reuse.
 Supplemental information
  • MIXTURE LIST-Contain: 5-chloro-2-methylisothiazol-3(2H)-one
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