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GSK-872, MedChemExpress

Product Code. 16472796
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Product Code. 16472796

Brand: Medchem Express HY101872

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Description

MedChemExpress GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

Specifications

Chemical Name or Material GSK-872
CAS 1346546-69-7
Color Off-White
Purity Grade Notes Research
Molecular Formula C19H17N3O2S2
Quantity 25 mg
Solubility Information DMSO : 100 mg/mL (260.76 mM; Need ultrasonic)
SMILES O=S(C1=CC=C2N=CC=C(C2=C1)NC3=CC=C4SC=NC4=C3)(C(C)C)=O
Molecular Weight (g/mol) 383.49
Formula Weight 383.49
Percent Purity 98.0%
Grade Research
Physical Form Powder
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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