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  5. Tocris Bioscience™ VH 298

Tocris Bioscience™ VH 298
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Product Code. 18721378
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18721378

Brand: Tocris Bioscience™ 6156/10

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This item is not returnable. View return policy

Description

High-affinity inhibitor of VHL

VH 298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.

Negative control cis VH 298 also available.

TRUSTED_SUSTAINABILITY

Specifications

Quantity 10 mg
Target Ubiquitin Ligase (E3)
Molecular Formula C27H33N5O4S
Formula Weight 523.65g/mol
Product Type Inhibitor

For Research Use Only

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