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TX1-85-1, MedChemExpress

Product Code. 16495917
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5 mg
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Product Code. 16495917

Brand: Medchem Express HY100848

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Description

MedChemExpress TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

Specifications

Chemical Name or Material TX1-85-1
CAS 1603845-32-4
Color White
Purity Grade Notes Research
Molecular Formula C32H36N8O3
Quantity 5 mg
Solubility Information DMSO : 3.85 mg/mL (6.63 mM; Need ultrasonic)
SMILES CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O
Molecular Weight (g/mol) 580.68
Formula Weight 580.68
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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