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Tocris Bioscience™ Tolcapone
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COMT inhibitor; also inhibits transthyretin aggregation

Brand:  Tocris Bioscience™ 5864/50

Encompass

Product Code. 15727376

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Description

Description

Tolcapone is a COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.
Specifications

Specifications

(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
134308-13-7
Tasmar, Ro 40-7592
50 mg
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