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TNF alpha Monoclonal Antibody (E10041), Biotin, Invitrogen™

Product Code. 11844271
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Quantity:
50 μg
Unit Size:
100µg
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11844271 50 μg 100µg
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Product Code. 11844271 Supplier Invitrogen Supplier No. M3TNFABI

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Description

Mouse Monoclonal Antibody

M3TNFABI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa. M3TNFABI targets TNF Alpha in ELISA and Western blot applications and shows reactivity with Canine, Feline, Human, Non-human primate, and Porcine samples. The MTNFAI antibody (clone E10043) has successfully been paired as the coating antibody in a sandwich ELISA with detection antibody M3TNFABI (biotinylated conjugate of clone E10041). The M3TNFABI immunogen is recombit human TNF alpha from Pichia pastoris. Lyophilized antibody should be reconstituted with 0.5 ml of distilled or deionized water to make a 0.1 mg/ml solution.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNF alpha
Applications ELISA, Western Blot
Classification Monoclonal
Clone E10041
Concentration 0.1 mg/mL
Conjugate Biotin
Gene TNF
Gene Accession No. P51742, P19101, P01375, P23563
Gene Alias APC1 protein; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; cachectin; tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
Gene Symbols TNF
Host Species Mouse
Immunogen Recombit human TNF alpha from Pichia pastoris.
Purification Method Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 397086, 403922, 493755, 7124
Target Species Canine, Feline, Human, Non-human Primate, Pig
Content And Storage 4° C
Product Type Antibody
Form Lyophilized
Isotype IgG1
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