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Temuterkib, MedChemExpress

Product Code. 16450769
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Product Code. 16450769

Brand: Medchem Express HY101494

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Description

MedChemExpress Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

Specifications

Chemical Name or Material Temuterkib
Physical Form Solid
CAS 1951483-29-6
Color Light Yellow
Quantity 1 mg
Purity Grade Notes Research
Molecular Formula C22H27N7O2S
For Use With (Application) Cancer-Kinase/protease
Synonym LY3214996
Solubility Information DMSO : 20 mg/mL (44.10 mM; Need ultrasonic)
SMILES O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5
Molecular Weight (g/mol) 453.56
Formula Weight 453.56
Percent Purity 99.54%
Grade Research
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Research purposes only

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