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Takinib, MedChemExpress

Product Code. 16496577
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Product Code. 16496577 Supplier Medchem Express Supplier No. HY103490

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Description

MedChemExpress Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively.

Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM).

Specifications

Chemical Name or Material Takinib
Physical Form Solid
CAS 1111556-37-6
Color White
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C18H18N4O2
For Use With (Application) Cancer-Kinase/protease
Synonym EDHS-206
Solubility Information DMSO : 50 mg/mL (155.11 mM; Need ultrasonic)
SMILES CCCN1C2=CC=CC=C2N=C1NC(C3=CC(C(N)=O)=CC=C3)=O
Molecular Weight (g/mol) 322.36
Formula Weight 322.36
Percent Purity 99.15%
Grade Research
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