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  5. Tocris Bioscience™ Takinib

Tocris Bioscience™ Takinib
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Product Code. 18778356
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5 mg
25 mg
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25mg
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18778356 5 mg 5mg
18708756 25 mg 25mg
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Product Code. 18778356 Supplier Tocris Bioscience™ Supplier No. 6430/5

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Description

Potent and selective TAK1/MAP3K7 kinase inhibitor

Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC50 = 8.2-9.5 nM). Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC50 values = 120, 390, 430, 430 and 1900 nM, respectively). Demonstrates weak inhibition at Src and Yes1. Exhibits no inhibition of MAP2K or other MAP3K family members. Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N1-(1-Propyl-1 H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
CAS 1111556-37-6
Quantity 5 mg
Target Other Kinase Inhibitors
Molecular Formula C18H18N4O2
Purity 0.98
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