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TAK-285, MedChemExpress

Product Code. 16496358
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Product Code. 16496358 Supplier Medchem Express Supplier No. HY15196

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Description

MedChemExpress TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity. TAK-285 can cross the blood-brain barrier (BBB).

TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity. TAK-285 can cross the blood-brain barrier (BBB).

Specifications

Chemical Name or Material TAK-285
CAS 871026-44-7
Color Off-White
Purity Grade Notes Research
Molecular Formula C26H25ClF3N5O3
Quantity 10 mg
Solubility Information DMSO : ≥ 50 mg/mL (91.25 mM)
SMILES ClC(C=C(NC1=NC=NC2=C1N(CCNC(CC(C)(C)O)=O)C=C2)C=C3)=C3OC4=CC=CC(C(F)(F)F)=C4
Molecular Weight (g/mol) 547.96
Formula Weight 547.96
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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