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Invitrogen™ SV40 T-Antigen Monoclonal Antibody (PAb419)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA190660
This item is not returnable.
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Description
This antibody recognizes the 94 kDa SV40 large T antigen and the 20.5 kDa SV40 small T antigen. Recommended positive controls include SV80 or SV-T2 cells.
The SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition, the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.
Specifications
| SV40 T-Antigen | |
| Monoclonal | |
| 0.1 mg/mL | |
| 0.05M sodium phosphate with 0.2% gelatin and 0.1% sodium azide | |
| Mouse | |
| Antigen affinity chromatography | |
| RUO | |
| Virus | |
| Antibody | |
| IgG2a |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| PAb419 | |
| Unconjugated | |
| simian vacuolating virus 40; simian virus; Simian virus 40; SV40 T-antigen; sv40 virus large t antigen | |
| Full length protein (SV40). | |
| 500 μL | |
| Primary | |
| 4°C, do not freeze | |
| Liquid |
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