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STEMCELL Technologies STAT5 Inhibitor

Product Code. 17140282
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5 mg
Unit Size:
5mg
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17140282 5 mg 5mg
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Product Code. 17140282 Supplier STEMCELL Technologies Supplier No. 73852

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Description

JAK/STAT pathway inhibitor; Inhibits STAT5

  • STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that specifically suppresses STAT5 (IC50 = 47 μM) via binding to its SH2 domain
  • It shows reduced potency towards the SH2 domains of STAT1, STAT3, or LCK (Müller et al.)
  • Induces partial apoptosis of mature eosinophils at high concentrations (Schwartz et al.)
  • Rescues IL-17 production in a proportion of restimulated TH17 clones (Zielinski et al.)
  • Reduces growth of induced regulatory T cells (iTregs) in vitro (Betts et al.)

Specifications

CAS 285986-31-4
Quantity 5 mg
Molecular Formula C16H11N3O3
Purity ≥95%
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