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SPIB Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16805094 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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16805094 150 μL 150µL
16815094 20 μL 20µL
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Product Code. 16805094 Supplier Proteintech Supplier No. 157681AP150UL

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Description

Rabbit Polyclonal Antibody

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5′-GAGGAA-3′) that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.

Specifications

Antigen SPIB
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene SPIB
Gene Accession No. O35906, Q01892, Q5EBA3
Gene Alias SPI B, SPIB, Transcription factor Spi B
Gene Symbols Spib
Host Species Rabbit
Immunogen SPIB Fusion Protein Ag8404
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 272382, 499146, 6689
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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