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Sorafenib, MedChemExpress

Product Code. 16474756
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Product Code. 16474756 Supplier Medchem Express Supplier No. HY10201

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Description

MedChemExpress Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator.

Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator.

Specifications

Chemical Name or Material Sorafenib
CAS 284461-73-0
Color Off-White
Purity Grade Notes Research
Molecular Formula C21H16ClF3N4O3
Quantity 100 mg
Synonym Bay 43-9006
Solubility Information DMSO : ≥ 45 mg/mL (96.81 mM)
SMILES O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Molecular Weight (g/mol) 464.83
Formula Weight 464.83
Percent Purity 99.25%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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