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Invitrogen™ SMO Polyclonal Antibody
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Product Code. 16610845 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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16610845 100 μL 100µL
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Product Code. 16610845 Supplier Invitrogen™ Supplier No. PA5104390

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SMO.

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMO
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SMO
Gene Accession No. P56726, P97698, Q99835
Gene Alias bent body; bnb; E130215L21Rik; frizzled family member 11; FZD11; Gx; HGNC:11119; Protein Gx; Protein SMOH; seven transmembrane helix receptor; SMO; SMOH; smoothened; Smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled class receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Gene Symbols SMO
Host Species Rabbit
Immunogen A synthesized peptide derived from human SMO(Accession Q99835), corresponding to amino acid residues N76-L126.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25273, 319757, 6608
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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