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  8. SKF-96365 hydrochloride, MedChemExpress

SKF-96365 hydrochloride, MedChemExpress

Product Code. 16485467
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Product Code. 16485467 Supplier Medchem Express Supplier No. HY1000015mg

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Description

MedChemExpress SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2+ entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.

SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2+ entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.

Specifications

Chemical Name or Material SKF-96365 hydrochloride
CAS 130495-35-1
Color White
Purity Grade Notes Research
Molecular Formula C22H27ClN2O3
Quantity 5 mg
Solubility Information DMSO : 100 mg/mL (248.19 mM; Need ultrasonic) ∣H2O : 100 mg/mL (248.19 mM; Need ultrasonic)
SMILES COC1=CC=C(CCCOC(C2=CC=C(OC)C=C2)CN3C=CN=C3)C=C1.[H]Cl
Molecular Weight (g/mol) 402.91
Formula Weight 402.91
Percent Purity 99.51%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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