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Tocris Bioscience™ SJ 6986

Product Code. 18726526
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18726526 10 mg 10mg
18705596 50 mg 50mg
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Product Code. 18726526 Supplier Tocris Bioscience™ Supplier No. 7720/10

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203.20 EUR valid until 2026-03-31
BEST PRICE on Promo! Use promo code "27931" to get your promotional price.
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Description

Molecular glue; induces degradation of GSPT1/2

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo, SJ 6986 is stable in mouse (t1/2 = 4.7 h). This product is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
CAS 2765625-93-0
Quantity 10 mg
Target Molecular Glues
Molecular Formula C20H14F3N3O7S
Purity 0.98
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