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Description
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
Specifications
Specifications
| Antigen | SHKBP1 |
| Applications | Immunocytochemistry, Immunofluorescence, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.15 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | SHKBP1 |
| Gene Accession No. | P0C5J9, Q6P7W2, Q8TBC3 |
| Gene Alias | PP203, Sb1, SH3KBP1 binding protein 1, SHKBP1 |
| Gene Symbols | SHKBP1 |
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Product Title
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