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Invitrogen™ SCK Polyclonal Antibody
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Product Code. 15534221
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
15534221 100 μL 100µL
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Product Code. 15534221 Supplier Invitrogen™ Supplier No. PA537052

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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 68 kDa. Purity is >95% by SDS-PAGE.

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCK
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide; pH 7.2
Gene SHC2
Gene Accession No. O70142, P98077, Q8BMC3
Gene Alias 6720466E06; neuronal Shc adaptor homolog; protein Sck; Protein Sli; SCK; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC adaptor protein 2; SHC2; ShcB; SHC-transforming protein 2; SHC-transforming protein B; SLI; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2
Gene Symbols SHC2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 339-384 of human SCK.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216148, 25759, 314612
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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