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  5. Tocris Bioscience™ RKI 1447 dihydrochloride

Tocris Bioscience™ RKI 1447 dihydrochloride
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Product Code. 18770929
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18770929 10 mg 10mg
18751789 50 mg 50mg
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Product Code. 18770929 Supplier Tocris Bioscience™ Supplier No. 5061/10

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237.20 EUR valid until 2026-03-31
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Description

Potent and selective ROCK inhibitor; antitumor

RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor (IC50 values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

CAS 1782109-09-4
Quantity 10 mg
Product Type RKI 1447 dihydrochloride
Purity >99%
Molecular Weight (g/mol) 399.29
Inhibitors RKI 1447 dihydrochloride

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