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  5. Tocris Bioscience™ RKI 1447 dihydrochloride

Tocris Bioscience™ RKI 1447 dihydrochloride
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Product Code. 18751789
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18751789

Brand: Tocris Bioscience™ 5061/50

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This item is not returnable. View return policy

Description

Potent and selective ROCK inhibitor; antitumor

RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor (IC50 values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

CAS 1782109-09-4
Quantity 50 mg
Product Type RKI 1447 dihydrochloride
Purity >99%
Molecular Weight (g/mol) 399.29
Inhibitors RKI 1447 dihydrochloride

For Research Use Only

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