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Invitrogen™ RIM1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5140003
This item is not returnable.
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Description
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: ENDRHSRKSE RSSIQKQTRK GTASDAERVL PTCLSRRGHA APRATDQPVI RGKHPARSRS SEHSSIRTLC SMHHL Highest antigen sequence indentity to the following orthologs: Rat - 85%, Mouse - 91%.
Rims1 is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. Rims1 also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations in the Rims1 gene have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Further, Rims1 may act as scaffold protein that regulates neurotransmitter release at the active zone. Rims1 may also be essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Rims1 also plays a role in dendrite formation by melanocytes. Multiple transcript variants encoding different isoforms have been described for this Rims1. Diseases associated with RIMS1 include Cone-Rod Dystrophy 7 and Retinitis Pigmentosa.
Specifications
| RIM1 | |
| Polyclonal | |
| Unconjugated | |
| Rims1 | |
| C030033M19Rik; CORD7; Kiaa0340; mKIAA0340; Nbla00761; Rab3 effector; Rab3 interacting protein 1; Rab-3-interacting molecule 1; rab3-interacting molecule 1; rab-3-interacting protein 1; rab3-interacting protein 1; Rab-3-interacting protein 2; RAB3-interacting protein 2; Rab3ip1; RAB3IP2; regulating synaptic membrane exocytosis 1; regulating synaptic membrane exocytosis 1 beta; regulating synaptic membrane exocytosis protein 1; Rim; RIM 1; RIM1; RIM1a; RIM1alpha; Rim1b protein; Rims1; Serg1; synaptic exocytosis regulator 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 22999 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q86UR5 | |
| Rims1 | |
| Recombinant protein corresponding to Human RIMS1. Recombinant protein control fragment (Product #RP-109568). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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