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RGB-286638 free base, MedChemExpress

Product Code. 16489147
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Product Code. 16489147 Supplier Medchem Express Supplier No. HY15504A

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Description

MedChemExpress RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.

RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively

Specifications

Chemical Name or Material RGB-286638 free base
Physical Form Solid
CAS 784210-88-4
Color Yellowish Green
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C29H35N7O4
For Use With (Application) Cancer-Kinase/protease
Solubility Information DMSO : 2.6 mg/mL (4.77 mM; Need ultrasonic)
SMILES O=C(NN1CCOCC1)NC2=CC=CC(C3=C4C(C5=CC=C(CN6CCN(CCOC)CC6)C=C5)=NN3)=C2C4=O
Molecular Weight (g/mol) 545.63
Formula Weight 545.63
Percent Purity 95.0%
Grade Research
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Research purposes only

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