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STEMCELL Technologies Refametinib
MEK/ERK Pathway Inhibitor; Inhibits MEK1 and MEK2
182.25 €
Specifications
CAS | 923032-37-5 |
---|---|
Synonym | BAY-86-9766; RDEA119 |
Molecular Formula | C19H20F3IN2O5S |
Purity | ≥95% |
Description
- Refametinib is an inhibitor of both mitogen-activated protein kinase kinases 1 (MEK1) and 2 (MEK2) with IC50 values of 19 and 47 nM respectively
- It binds in an allosteric site adjacent to the ATP pocket and is selective for MEK1/2 versus 205 other kinases (Iverson et al.)
Specifications
923032-37-5 | |
BAY-86-9766; RDEA119 | |
C19H20F3IN2O5S | |
≥95% |
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