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Gibco™ Rat GM-CSF, Animal-Free Recombinant Protein, PeproTech®

Product Code. 17863753
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Quantity:
1 mg
100 μg
20 μg
500 μg
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100µg
1mg
20µg
500µg
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Artikelnummer. 17863753

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Beschreibung

Recombinant Protein

Recombinant Rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Spezifikation

Accession Number P48750
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 116630
Molecular Weight (g/mol) 14.5 kDa
Name Rat GM-CSF, Animal-Free
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Common Name GM-CSF
Gene Symbol CSF2
Biological Activity Determined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The expected ED50 is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 10^8 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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