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Purvalanol B, MedChemExpress

Product Code. 16463517
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Quantity:
5 mg
10 mg
50 mg
Unit Size:
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50mg
5mg
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Product Code. 16463517

Brand: Medchem Express HY18299

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Description

MedChemExpress Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum.

Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum.

Specifications

Chemical Name or Material Purvalanol B
CAS 212844-54-7
Color White
Purity Grade Notes Research
Molecular Formula C20H25ClN6O3
Quantity 50 mg
Synonym NG 95
Solubility Information DMSO : ≥ 40 mg/mL (92.40 mM)
SMILES O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl
Molecular Weight (g/mol) 432.9
Formula Weight 432.9
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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