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Invitrogen™ PRR5L Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5107224
This item is not returnable.
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Description
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%.
Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
Specifications
| PRR5L | |
| Polyclonal | |
| Unconjugated | |
| PRR5L | |
| 2600010E01Rik; 4833411O04Rik; proline rich 5 like; proline-rich protein 5-like; Protein observed with Rictor-2; PROTOR2; protor-2; Prr5l | |
| Rabbit | |
| Protein A | |
| RUO | |
| 79899 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 2% sucrose and 0.09% sodium azide; pH 7.4 | |
| Q6MZQ0 | |
| PRR5L | |
| Synthetic peptide directed towards the N terminal region of human FLJ14213. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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