Thermo Scientific™ Proteome Discoverer™ Software

Proteome Discoverer software supports multiple dissociation techniques, quantitation technologies, and database search algorithms for comprehensive protein identification, characterization, and quantitation.

Comprehensive

• Provides a choice of search algorithms (SEQUEST™ HT, Mascot, MS Amanda, Byonic™, ProsightPD™) and can combine output from multiple algorithms to maximize and cross-validate results
• Find more with the intelligent INFERYS Rescoring and CHIMERYS algorithms
• Supports multiple dissociation techniques (HCD, CID, ETD, and UVPD) for more complete coverage and confident identification of PTMs
• Supports isobaric mass tagging (TMT, iTRAQ), isotopic labeling (SILAC), and label-free quantification
• Validates peptide and protein IDs with false discovery rate (FDR)

Productive and Extensible

• Automates data analysis and simplifies MSⁿ data analysis through pre-built and customizable workflows
• Includes study management for mapping of quantitation to biological information about the sample
• Use results to refine data collecting, such as exporting inclusion and exclusion lists for import directly into instrument methods
• Illustrates biological context by automatically annotating identified proteins with GO classifications, PTM sites, and literature references from public databases
• Facilitates data comparison, exchange, and verification with support for data standards developed by the HUPO Proteomics Standards Initiative (PSI)
• Supports third party nodes for data processing and enables processing of large datasets
• Fast, robust algorithms empowered by artificial intelligence for peak selection and peptide quantification to extract more information
• Obtain reliable statistics and validate quantification results visually