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PRN694, MedChemExpress

Product Code. 16445288
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Product Code. 16445288 Supplier Medchem Express Supplier No. HY12680

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Description

MedChemExpress PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo.

PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo.

Specifications

Chemical Name or Material PRN694
CAS 1575818-46-0
Color Light Brown
Purity Grade Notes Research
Molecular Formula C28H35F2N5O2S
Quantity 10 mg
Solubility Information DMSO : 125 mg/mL (229.92 mM; Need ultrasonic and warming)
SMILES O=C(C1=CC=C(C(F)F)S1)NC2=NC3=CC(CN[C@@H](C)C(C)(C)C)=CC=C3N2C[C@@H]4N(C(C=C)=O)CCC4
Molecular Weight (g/mol) 543.67
Formula Weight 543.67
Percent Purity 99.0%
Grade Research
Physical Form Powder
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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