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Invitrogen™ PRL1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5106431
This item is not returnable.
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Description
Antibody detects endogenous levels of total PTP4A1/PRL1.
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.
Specifications
| PRL1 | |
| Polyclonal | |
| Unconjugated | |
| PTP4A1 | |
| AA415290; AU019864; C130021B01; DKFZp779M0721; HH72; PRL1; Prl-1; protein tyrosine phosphatase 4a1; protein tyrosine phosphatase type IVA 1; protein tyrosine phosphatase type IVA protein 1; protein tyrosine phosphatase type IVA, member 1; protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PTP(CAAX1); PTP(CAAXI); PTP4A1; PTP4A1 protein; PTP4A2; PTPCAAX1; RP5-1148A21.2 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 19243, 29463, 7803 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q63739, Q78EG7, Q93096 | |
| PTP4A1 | |
| A synthesized peptide derived from human PTP4A1(Accession Q93096), corresponding to amino acid residues N142-Q173. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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